A cowardly geek named Columbus (Eisenberg) is forced to join up with a hard-man zombie slayer named Tallahassee (Harrelson) in order to survive the zombie apocalypse.
Two of the few non-zombies remaining on the planet, Tallahassee and Columbus set out on a mission to find the last Twinkie on Earth.
They come across Wichita (Stone) and Little Rock (Breslin), young sisters who have resorted to some rather unorthodox methods to survive amidst the chaos.
Reluctant partners in the battle against the undead, all four soon begin to wonder if they might actually be better off taking their chances alone.